产品名称
雷帕霉素, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
assay
≥95% (HPLC)
form
solution
manufacturer/tradename
Calbiochem®
storage condition
desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
Quality Level
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General description
选择性抑制 p70 S6 激酶的磷酸化和激活（IC50 = 50 pM）。防止 IGF-II 的翻译激活。还防止静止的 T 细胞进入细胞周期，但不直接阻止细胞周期进程。研究表明，可抑制随后的信号传导事件，例如 p110Rb 磷酸化、p34cdc2 激酶激活和细胞周期蛋白 A 合成。表现出与 FK-50 6结合蛋白的强结合力。还据报道在鼠 B 细胞系中诱导凋亡，抑制淋巴因子诱导的细胞增殖（在 G1 期），并不可逆地阻滞酿酒酵母细胞（在 G1 期）。
Biochem/physiol Actions
主靶
雷帕霉素（mTOR）的哺乳动物靶标
雷帕霉素（mTOR）的哺乳动物靶标
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：50 pM 抑制雷帕霉素（mTOR）的哺乳动物靶标，并阻断随后的 p70 S6 激酶的激活
Packaging
用惰性气体包装
Physical form
在DMSO中的溶液浓度为2.5 mg/mL（2.74 mM）
Preparation Note
初次使用后，等分并冷冻（-20°C）。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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