554718
REV-ERBα Antagonist, SR8278
The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.
别名:
REV-ERBα Antagonist, SR8278, SR8278SR 8278
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关于此项目
经验公式（希尔记法）:
C18H19NO3S2
化学文摘社编号:
分子量:
361.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
JRLOEMCOOZSCQP-UHFFFAOYSA-N
SMILES string
n1c2c(ccc1COc3cc(ccc3)C(O)CCCCC)cccc2
assay
>95% (HPLC)
form
gum, solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to yellow-brown
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Other Notes
Kojetin, D., et al. 2010, Chem Bio in press
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fang-Yuan Mao et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 395-425 (2021-03-07)
Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. Rev-erbα was examined in gastric samples from H pylori-infected patients and mice. Gastric epithelial cells (GECs)
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