554718
REV-ERBα Antagonist, SR8278
The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.
别名:
REV-ERBα Antagonist, SR8278, SR8278SR 8278
质量水平
方案
>95% (HPLC)
表单
gum
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white to yellow-brown
溶解性
DMSO: 25 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
n1c2c(ccc1COc3cc(ccc3)C(O)CCCCC)cccc2
InChI key
JRLOEMCOOZSCQP-UHFFFAOYSA-N
一般描述
A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
其他说明
Kojetin, D., et al. 2010, Chem Bio in press
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Regulatory Review (Z)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Fang-Yuan Mao et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 395-425 (2021-03-07)
Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. Rev-erbα was examined in gastric samples from H pylori-infected patients and mice. Gastric epithelial cells (GECs)
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