质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white to off-white
溶解性
DMSO: 25 mg/mL
ethanol: 25 mg/mL
运输
ambient
储存温度
10-30°C
InChI
1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
InChI key
RXSVYGIGWRDVQC-UHFFFAOYSA-N
一般描述
Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.
生化/生理作用
Cell permeable: no
Primary Target
DAG lipase
DAG lipase
Product does not compete with ATP.
Reversible: no
Target IC50: 4 nM against DAG lipase activity in canine platelets
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持