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Merck
CN

554994

RHC-80267

Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells.

别名:

RHC-80267, 1,6- bis(Cyclohexyloximinocarbonylamino)hexane

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关于此项目

经验公式（希尔记法）:
C20H34N4O4
化学文摘社编号:
83654-05-1
分子量:
394.51
NACRES:
NA.77
UNSPSC Code:
51111800
MDL number:
MFCD00210844

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InChI

1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)

InChI key

RXSVYGIGWRDVQC-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

DMSO: 25 mg/mL, ethanol: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

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相关类别

General description

Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biochem/physiol Actions

Cell permeable: no
Primary Target
DAG lipase
Product does not compete with ATP.
Reversible: no
Target IC50: 4 nM against DAG lipase activity in canine platelets

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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