555551
Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem
The Rho Kinase Inhibitor II, also referenced under CAS 97627-27-5, controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem, N-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea
质量水平
方案
≥95% (HPLC)
表单
solid
效能
0.2 μM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A potent, selective, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 200 nM). Does not significantly inhibit the activities of Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 >10 µM).
A pyridyl urea compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 0.2 µM). Displays little activity towards Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 >10 µM).
生化/生理作用
Cell permeable: no
Primary Target
ROCK
ROCK
Product competes with ATP.
Reversible: yes
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Takami, A., et al. 2004. Bioorg. Med. Chem.12, 2115.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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