555551
Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem
The Rho Kinase Inhibitor II, also referenced under CAS 97627-27-5, controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem, N-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea
assay
≥95% (HPLC)
form
solid
potency
0.2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
ROCK
ROCK
Product competes with ATP.
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A potent, selective, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 200 nM). Does not significantly inhibit the activities of Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 >10 µM).
A pyridyl urea compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 0.2 µM). Displays little activity towards Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 >10 µM).
Other Notes
Takami, A., et al. 2004. Bioorg. Med. Chem.12, 2115.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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