557324
Riluzole
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
别名:
Riluzole, 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
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关于此项目
经验公式（希尔记法）:
C8H5F3N2OS
化学文摘社编号:
分子量:
234.20
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Riluzole, A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
SMILES string
FC(F)(F)Oc1cc2[s]c(nc2cc1)N
InChI
1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChI key
FTALBRSUTCGOEG-UHFFFAOYSA-N
description
Merck USA index - 14, 8223
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to off-white
solubility
HCl: 0.1 N
DMSO: 40 mg/mL
cation traces
heavy metals: ≤20 ppm
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Inhibits glutamate release and blocks Na+ channels
Inhibits glutamate release and blocks Na+ channels
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Toxic (F)
General description
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD).
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.
Schiefer, J., et al. 2002. Mov. Disord.17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett.310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196.
Mizoule, J., et al. 1985. Neuropharmacology24, 767.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
Ken-Ichi Dewa et al.
Nature communications, 15(1), 458-458 (2024-02-02)
In the central nervous system, astrocytes enable appropriate synapse function through glutamate clearance from the synaptic cleft; however, it remains unclear how astrocytic glutamate transporters function at peri-synaptic contact. Here, we report that Down syndrome cell adhesion molecule (DSCAM) in
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