557450
钌红
Calcium channel blocker, solid
别名:
钌红, 氨化氯氧化钌，RR
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关于此项目
线性分子式:
[(NH3)5RuORu(NH3)4ORu(NH3)5]Cl6
化学文摘社编号:
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
产品名称
钌红, A blocker of transmembrane Ca2+ fluxes (IC50 = 7 µM) that attenuates capsaicin-induced cation channel opening.
description
Merck USA index - 14, 8300
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
red-black
solubility
ammonia: soluble, water: soluble
shipped in
ambient
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
细胞可渗透性：否
可逆：否
主靶
跨膜Ca2+通量的阻断剂
跨膜Ca2+通量的阻断剂
产物不与ATP竞争。
靶标IC50：7 µM阻断跨膜Ca2+通量；6 µM抑制K+-刺激的儿茶酚胺分泌
Disclaimer
毒性：有害（C）
General description
一种跨膜Ca2+通量阻滞剂（IC50 = 7 µM），可减弱辣椒素诱导的阳离子通道开放。抑制从对兰尼碱敏感的细胞内Ca2+贮藏中，Ca2+-诱导的Ca2+释放。抑制K+-刺激的儿茶酚胺分泌(IC50 = 6 µM)。
Other Notes
Merck Index 13, 8379.
Phillippe, M. and Basa, A. 1996.Biochem.Biophys.Res. Commun.221, 656.
Buratti, R., et al. 1995.Biochem.Biophys.Res. Commun.213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995.J. Pharmacol.Exp.Ther.273, 940.
Gomis, A., et al. 1994.Biochem.Pharmacol.47, 225.
Stjame, P., et al. 1994.Acta Otolaryngol.114, 651.
Ma, J. 1993.J. Gen.Physiol.102, 1031.
Phillippe, M. and Basa, A. 1996.Biochem.Biophys.Res. Commun.221, 656.
Buratti, R., et al. 1995.Biochem.Biophys.Res. Commun.213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995.J. Pharmacol.Exp.Ther.273, 940.
Gomis, A., et al. 1994.Biochem.Pharmacol.47, 225.
Stjame, P., et al. 1994.Acta Otolaryngol.114, 651.
Ma, J. 1993.J. Gen.Physiol.102, 1031.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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