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557502

Ro-20-1724

Name: Ro-20-1724
Brand: MM

≥98% (TLC), solid, cAMP phosphodiesterase inhibitor, Calbiochem

别名:

Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₂N₂O₃

化学文摘社编号:

29925-17-5

分子量:

278.35

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00077397

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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属性

产品名称

Ro-20-1724, A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM).

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 20%, ethanol: 4%

shipped in

ambient

storage temp.

10-30°C

SMILES string

N1C(CNC1=O)Cc2cc(c(cc2)OC)OCCCC

InChI

1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)

InChI key

PDMUULPVBYQBBK-UHFFFAOYSA-N

说明

General description

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE IV

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2 µM against PDE IV

Other Notes

Derian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol.115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol.13, 38.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c