557525
Ro-32-0432
A selective cell-permeable protein kinase C inhibitor.
别名:
Ro-32-0432
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选择尺寸
关于此项目
经验公式（希尔记法）:
C28H28N4O2 · xHCl
化学文摘社编号:
分子量:
452.55 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
Ro-32-0432, A selective cell-permeable protein kinase C inhibitor.
SMILES string
Cl.[n]21c3c(cc2CC(CC1)CN(C)C)ccc(c3)C4=C(C(=O)NC4=O)c5c6c([n](c5)C)cccc6
InChI
1S/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H
InChI key
WMVQGKBSNAIMHI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
red
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
主要靶标
PKCα
PKCα
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：对于PKCα，PKCβI和PKCε分别为9 nM、28 nM、108 nM
Disclaimer
毒性：标准处理（A）
General description
一种选择性的细胞渗透性蛋白激酶C抑制剂。与ε (IC50=108 nM）相比，PKCα (IC50=9 nM）的选择性提高约10倍，PKCβI (IC50=28 nM）的选择性提高4倍。还可以防止体内T细胞驱动的慢性炎症反应。
请注意，由于水含量的变化，该化合物的分子量因批次而异。
请注意，由于水含量的变化，该化合物的分子量因批次而异。
Other Notes
Birchall, A.M., et al. 1994.J. Pharmacol.Exp.Ther.268, 922.
Wilkinson, S.E., et al. 1993.Biochem.J.294, 335.
Wilkinson, S.E., et al. 1993.Biochem.J.294, 335.
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多4个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
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