559393-M
SB 202190, Hydrochloride
A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.
别名:
SB 202190, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
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关于此项目
经验公式（希尔记法）:
C20H14FN3O · xHCl
化学文摘社编号:
分子量:
331.34 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)O.Cl
InChI
1S/C20H14FN3O.ClH/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;/h1-12,25H,(H,23,24);1H
InChI key
XOQSUTIMRLPFPB-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
potency
16 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
amber
solubility
water: 0.5 mg/mL (slightly soluble), DMSO: soluble
storage temp.
−20°C
Quality Level
General description
A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
Biochem/physiol Actions
Target IC50: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
Preparation Note
Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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