559396
SB 220025
A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM).
别名:
SB 220025, 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
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关于此项目
经验公式（希尔记法）:
C18H19FN6
化学文摘社编号:
分子量:
338.38
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
产品名称
SB 220025, A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM).
SMILES string
Fc1ccc(cc1)c2nc[n](c2c4nc(ncc4)N)C3CCNCC3
InChI
1S/C18H19FN6/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24)
InChI key
VSPFURGQAYMVAN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
potency
60 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white to pale yellow
solubility
DMSO: 22 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Primary Target
P38MAPK
P38MAPK
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
A potent and specific inhibitor of human p38 mitogen-activated protein (MAP) kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits >2500-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1600-fold over EGFRK. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
Other Notes
Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther.284, 687.
Wang, Z., et al. 1998. Structure6, 1117.
Wang, Z., et al. 1998. Structure6, 1117.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
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