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COA分析证书/COQ

559406

SB 328437

Name: SB 328437
Brand: MM

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.

别名:

SB 328437, (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate

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About This Item

经验公式（希尔记法）:

C₂₁H₁₈N₂O₅

CAS Number:

247580-43-4

分子量:

378.38

MDL编号:

MFCD16618397

UNSPSC代码:

12352200

质量水平

100

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1

InChI key

VMFGCGRAIBLAFY-IBGZPJMESA-N

一般描述

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of ¹²⁵I-eotaxin and ¹²⁵I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC₅₀ = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC₅₀ = 38, 35, and 20 nM, respectively).

生化/生理作用

Cell permeable: no

Primary Target
CC chemokine receptor-3 (CCR3)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

其他说明

White, J.R., et al. 2000. J. Biol. Chem.275, 36626.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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