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Merck
CN

565740

α-淀粉样蛋白前体蛋白质调节剂

≥95% (HPLC), solid, PKC activator, Calbiochem®

别名:

α-淀粉样蛋白前体蛋白质调节剂

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关于此项目

经验公式（希尔记法）:
C27H30F3N3O3
化学文摘社编号:
497259-23-1
分子量:
501.54
MDL number:
MFCD09037558
UNSPSC Code:
12352202
NACRES:
NA.77

主要文件

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产品名称

α-淀粉样蛋白前体蛋白质调节剂, A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.

SMILES string

FC(F)(F)c1ccc(cc1)\C=C\C=C\C(=O)Nc2cc3c(cc2)N([C@H](C(=O)N[C@@H](C3)CO)C(C)C)C

InChI

1S/C27H30F3N3O3/c1-17(2)25-26(36)32-22(16-34)15-19-14-21(12-13-23(19)33(25)3)31-24(35)7-5-4-6-18-8-10-20(11-9-18)27(28,29)30/h4-14,17,22,25,34H,15-16H2,1-3H3,(H,31,35)(H,32,36)/b6-4+,7-5+/t22-,25-/m0/s1

InChI key

WOLVEMPZUIFSII-IHHOKICGSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

orange

solubility

methanol: 1 mg/mL, DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

相关类别

General description

一种细胞渗透性PKC激活剂（PKCα的Ki=11.9 nM），有效增强淀粉样前体蛋白（APP）的非淀粉样α加工，但缺乏任何促肿瘤活性。
一种细胞渗透性苯并内酰胺衍生的PKC激活剂（PKCα的Ki=11.9 nM），即使在100 nM时，也可有效增强人成纤维细胞AG06848中淀粉样前体蛋白（APP）的非淀粉样α-加工。显示肿瘤促进活性显着丧失。

Biochem/physiol Actions

主要靶标
PKC
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标Ki：对于活化PKC为11.9 nMα

Packaging

用惰性气体包装

Preparation Note

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。

Other Notes

Kozikowski, A.P., et al. 2003.J. Med. Chem.46, 364.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：标准处理（A）

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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