跳转至内容
Merck
CN

565740

Sigma-Aldrich

α-淀粉样蛋白前体蛋白质调节剂

≥95% (HPLC), solid, PKC activator, Calbiochem®

别名:

α-淀粉样蛋白前体蛋白质调节剂

登录查看公司和协议定价

关于此项目

经验公式（希尔记法）:
C27H30F3N3O3
CAS Number:
497259-23-1
分子量:
501.54
MDL编号:
MFCD09037558
UNSPSC代码:
12352202
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

Product Name

α-淀粉样蛋白前体蛋白质调节剂, A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.

质量水平

100

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

orange

溶解性

methanol: 1 mg/mL
DMSO: 50 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

FC(F)(F)c1ccc(cc1)\C=C\C=C\C(=O)Nc2cc3c(cc2)N([C@H](C(=O)N[C@@H](C3)CO)C(C)C)C

InChI

1S/C27H30F3N3O3/c1-17(2)25-26(36)32-22(16-34)15-19-14-21(12-13-23(19)33(25)3)31-24(35)7-5-4-6-18-8-10-20(11-9-18)27(28,29)30/h4-14,17,22,25,34H,15-16H2,1-3H3,(H,31,35)(H,32,36)/b6-4+,7-5+/t22-,25-/m0/s1

InChI key

WOLVEMPZUIFSII-IHHOKICGSA-N

相关类别

一般描述

一种细胞渗透性PKC激活剂（PKCα的Ki=11.9 nM），有效增强淀粉样前体蛋白（APP）的非淀粉样α加工，但缺乏任何促肿瘤活性。
一种细胞渗透性苯并内酰胺衍生的PKC激活剂（PKCα的Ki=11.9 nM），即使在100 nM时，也可有效增强人成纤维细胞AG06848中淀粉样前体蛋白（APP）的非淀粉样α-加工。显示肿瘤促进活性显着丧失。

生化/生理作用

主要靶标
PKC
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标Ki：对于活化PKC为11.9 nMα

包装

用惰性气体包装

制备说明

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。

其他说明

Kozikowski, A.P., et al. 2003.J. Med. Chem.46, 364.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：标准处理（A）

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Sara Jiménez et al.
Cell reports methods, 3(7), 100512-100512 (2023-08-03)
Time-specific modulation of gene expression during differentiation by transcription factors promotes cell diversity. However, estimating their dynamic regulatory activity at the single-cell level and in a high-throughput manner remains challenging. We present FateCompass, an integrative approach that utilizes single-cell transcriptomics
Luiza Ghila et al.
Methods in molecular biology (Clifton, N.J.), 2454, 327-349 (2021-04-01)
Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.
Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture.
Braam, et al.
Scientific Reports, 13, 8877-8877 (2023)
Zhimin Zhou et al.
iScience, 27(7), 110291-110291 (2024-07-26)
KCNQ1/Kv7, a low-voltage-gated K+ channel, regulates cardiac rhythm and glucose homeostasis. While KCNQ1 mutations are associated with long-QT syndrome and type2 diabetes, its function in human pancreatic cells remains controversial. We identified a homozygous KCNQ1 mutation (R397W) in an individual
Nina Sofi Funa et al.
Stem cell reports, 19(7), 973-992 (2024-06-29)
Genetic differences between pluripotent stem cell lines cause variable activity of extracellular signaling pathways, limiting reproducibility of directed differentiation protocols. Here we used human embryonic stem cells (hESCs) to interrogate how exogenous factors modulate endogenous signaling events during specification of
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持