565750
γ-Secretase Inhibitor I
The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
γ-Secretase Inhibitor I, Z-LLNle-CHO
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
DMSO: 10 mg/mL, 50% acetic acid: soluble
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.
Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
γ-secretase
γ-secretase
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.
Z-Leu-Leu-Nle-CHO (Nle = Norleucine)
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Shreoshi Sengupta et al.
eLife, 11 (2022-06-02)
Cancer stem cells (CSCs) alone can initiate and maintain tumors, but the function of non-cancer stem cells (non-CSCs) that form the tumor bulk remains poorly understood. Proteomic analysis showed a higher abundance of the extracellular matrix small leucine-rich proteoglycan fibromodulin
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