565755
γ分泌酶抑制剂II
The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
γ分泌酶抑制剂II, MW167
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 10 mM
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
一种细胞渗透性、可逆性和选择性γ-分泌酶拟肽类抑制剂，IC50为13 µM，用于抑制β-淀粉样前体蛋白(APP)转染的中国仓鼠卵巢细胞中淀粉样β-蛋白(Aβ)的产生。对钙蛋白酶II仅显示微弱的抑制活性（在纯化酶测定中IC50=100 µM）。
Biochem/physiol Actions
主要靶标
γ-分泌酶
γ-分泌酶
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：γ-分泌酶为13 µM
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
Other Notes
Wolfe, M.S., et al. 1999.Biochemistry38, 4720.
Wolfe, M.S., et al. 1998.J. Med. Chem. 41, 6.
Citron, M., et al. 1996.Proc.Natl.Acad.Sci. USA93, 13170.
Wolfe, M.S., et al. 1998.J. Med. Chem. 41, 6.
Citron, M., et al. 1996.Proc.Natl.Acad.Sci. USA93, 13170.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yaxiong Yang et al.
Journal of neurochemistry, 88(6), 1361-1372 (2004-03-11)
Glutamate uptake by high affinity glutamate transporters is essential for preventing excitotoxicity and maintaining normal synaptic function. We have discovered a novel role for presenilin-1 (PS1) as a regulator of glutamate transport. PS1-deficient neurons showed a decrease in glutamate uptake
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