565761
γ-Secretase Inhibitor IV
The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
别名:
γ-Secretase Inhibitor IV, 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
质量水平
方案
≥95% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
−20°C
相关类别
一般描述
A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
生化/生理作用
Cell permeable: yes
ED50 = 2.6 µM for Aβx-40
Primary Target
Aβx-40
Aβx-40
Product does not compete with ATP.
Reversible: yes
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
2-Naphthoyl-Val-Phe-CHO
Green, K.N., et al. 2002. J. Physiol.541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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