A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ₄₂ (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APP_Sα, but no change in secreted APP_Sβ, indicating a specific inhibition of γ-secretase activity.

Cell permeable. Potently inhibits Aβ₄₂ production (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.

Cell permeable: yes

Primary Target
Aβ₄₂ production

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1.8 µM against Aβ42 production

Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Rishton, G.M., et al. 2000. J. Med. Chem.43, 2297.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)