565767
α-Secretase Substrate II, Fluorogenic
An internally quenched fluorogenic peptide substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP).
别名:
α-Secretase Substrate II, Fluorogenic, Ac-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
red
溶解性
DMSO: 5 mg/mL
荧光
λex ~340 nm
λem ~490 nm
运输
ambient
储存温度
−20°C
一般描述
An internally quenched fluorogenic peptide substrate that contains the α-secretase cleavage site of β-amyloid precursor protein (APP). Shown to be an effective substrate for yapsin-2, a glycosyl-phosphatidylinositol-linked aspartyl protease found in yeast (Vmax/Km = 0.031 min-1). The cleavage has been shown to occur at the Lys-Leu bond. Excitation max: ~340 nm; emission max: ~490 nm.
生化/生理作用
Cell permeable: no
Primary Target
Substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP)
Substrate containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP)
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
其他说明
Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH
Komano, H., et al. 1999. J. Biol. Chem. 274, 24431.
Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
Komano, H., et al. 1998. J. Biol. Chem. 273, 31648.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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