565792-M
γ-Secretase Inhibitor XXIII, Aβ42-Selective
The γ-Secretase Inhibitor XXIII, Aβ42-Selective controls the biological activity of γ-Secretase.
别名:
γ-Secretase Inhibitor XXIII, Aβ42-Selective
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
beige
溶解性
DMSO: 25 mg/mL
储存温度
2-8°C
一般描述
A cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
其他说明
Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett.20, 2279.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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