565850
紫草宁
≥98% (HPLC), solid, Pyruvate kinase inhibitor, Calbiochem®
别名:
紫草宁
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关于此项目
经验公式（希尔记法）:
C16H16O5
化学文摘社编号:
分子量:
288.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
紫草宁, A naphthoquinone found in the Chinese herb Shiunko.
SMILES string
OC(CC=C(C)C)C1=CC(=O)c2c(c(ccc2O)O)C1=O
InChI
1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3
InChI key
NEZONWMXZKDMKF-UHFFFAOYSA-N
description
RTECS - QL8000200
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
red
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
主靶
TNF-α-诱导和B16黑色素瘤诱导的血管生成
TNF-α-诱导和B16黑色素瘤诱导的血管生成
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
Disclaimer
毒性：标准处理（A）
General description
在中草药紫草中发现的萘醌。具有显著的抗菌、抗炎和抗肿瘤活性。抑制TNF-α和B-16黑色素瘤诱导的小鼠血管生成。在体外阻断整合素αVβ3的表达，并抑制内皮细胞增殖和迁移。还在HL60人早幼粒细胞白血病细胞系中诱导细胞凋亡。选择性阻断PKM2(IC50<1 µM)而非PKM1和PKL活性，（IC50在10-20 µM范围内），并抑制癌细胞糖酵解。
Other Notes
Chen, J., et al. 2011.Oncogene30, 4297.
Li, H., et al. 1999.Phytother.Res.13, 236.
Yoon, Y., et al. 1999.Planta Med.65, 532.
Hisa, T., et al. 1998.Anticancer Res. 18, 783.
Li, H., et al. 1999.Phytother.Res.13, 236.
Yoon, Y., et al. 1999.Planta Med.65, 532.
Hisa, T., et al. 1998.Anticancer Res. 18, 783.
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Zolzaya Sandag et al.
Molecules and cells, 43(3), 236-250 (2020-02-14)
Currently, many available anti-cancer therapies are targeting apoptosis. However, many cancer cells have acquired resistance to apoptosis. To overcome this problem, simultaneous induction of other types of programmed cell death in addition to apoptosis of cancer cells might be an
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