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关于此项目
经验公式(希尔记法):
C19H11N3Na2O7S2
化学文摘社编号:
分子量:
503.42
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
SHP1/2蛋白酪氨酸磷酸酶抑制剂,NSC-87877, The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
red-brown
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1
InChI
1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;
InChI key
YOGRUDWAJPVHEL-LLDDCTHSSA-L
General description
一种细胞渗透性7-氮杂-8-羟基喹啉化合物,作为SHP-1和SHP-2蛋白酪氨酸磷酸酶的有效催化靶向抑制剂(IC50分别为355 nM和318 nM)。它抑制PTP1B和HePTP的效力较低(IC50分别为1.69 µM和7.75 µM),并且比DEP1、CD45和LAR表现出>200倍的选择性。显示抑制HEK293细胞的基础和刺激SHP-2活性。
Biochem/physiol Actions
Cell permeable: yes
主要靶标
SHP1/2 PTPase
SHP1/2 PTPase
产物不与ATP竞争。
可逆:否
靶标IC50:针对SHP-1和SHP-2蛋白酪氨酸磷酸酶分别为355 nM和318 nM
Packaging
用惰性气体包装
Preparation Note
复溶后,等分并冷冻保存(-20°C)。贮备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Chen, L., et al. 2006.Mol.Pharmacol.70, 562.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性:标准处理(A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable