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Merck
CN

565851

Sigma-Aldrich

NSC-87877

≥97% (HPLC), solid, SHP1/2 PTPase inhibitor, Calbiochem®

别名:

SHP1/2蛋白酪氨酸磷酸酶抑制剂，NSC-87877, 8-羟基-7-(6-磺基萘-2-基)二氮烯基-喹啉-5-磺酸，二钠盐，HePTP抑制剂II，PTP抑制剂XXV，PTP1B抑制剂IV，SHP1抑制剂I，SHP2抑制剂I

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关于此项目

经验公式（希尔记法）:
C19H11N3Na2O7S2
CAS Number:
56932-43-5
分子量:
503.42
MDL编号:
MFCD00041863
UNSPSC代码:
12352200
NACRES:
NA.54

主要文件

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Product Name

SHP1/2蛋白酪氨酸磷酸酶抑制剂，NSC-87877, The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

质量水平

100

方案

≥97% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

red-brown

溶解性

water: 10 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1

InChI

1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;

InChI key

YOGRUDWAJPVHEL-LLDDCTHSSA-L

相关类别

一般描述

一种细胞渗透性7-氮杂-8-羟基喹啉化合物，作为SHP-1和SHP-2蛋白酪氨酸磷酸酶的有效催化靶向抑制剂（IC50分别为355 nM和318 nM）。它抑制PTP1B和HePTP的效力较低（IC50分别为1.69 µM和7.75 µM），并且比DEP1、CD45和LAR表现出>200倍的选择性。显示抑制HEK293细胞的基础和刺激SHP-2活性。

生化/生理作用

Cell permeable: yes
主要靶标
SHP1/2 PTPase
产物不与ATP竞争。
可逆：否
靶标IC50：针对SHP-1和SHP-2蛋白酪氨酸磷酸酶分别为355 nM和318 nM

包装

用惰性气体包装

制备说明

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

其他说明

Chen, L., et al. 2006.Mol.Pharmacol.70, 562.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：标准处理（A）

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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