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About This Item
经验公式（希尔记法）:
C22H15FN4O2S
CAS Number:
分子量:
418.44
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 100 mg/mL
运输
wet ice
储存温度
2-8°C
SMILES字符串
FC(C=C1)=CC=C1N2C(N)=C(S(C3=CC=CC=C3)(=O)=O)C4=C2N=C5C(C=CC=C5)=N4
InChI
1S/C22H15FN4O2S/c23-14-10-12-15(13-11-14)27-21(24)20(30(28,29)16-6-2-1-3-7-16)19-22(27)26-18-9-5-4-8-17(18)25-19/h1-13H,24H2
InChI key
CSFVFDHRYKBBPD-UHFFFAOYSA-N
一般描述
A cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10 µM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-α release in THP-1 cells by ~10-fold more potent than resveratrol (Cat. No. 554325).
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Lavu, S., et al. 2008. Nat. Rev. Drug Discov.7, 841.
Nayagam, V.M., et al. 2006. J. Biomol. Screen.11, 959.
Nayagam, V.M., et al. 2006. J. Biomol. Screen.11, 959.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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