566326
SIRT2 Inhibitor, Inactive Control, AGK7
The SIRT2 Inhibitor, Inactive Control, AGK7, also referenced under CAS 304896-21-7, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
SIRT2 Inhibitor, Inactive Control, AGK7, SIRT2 Inhibitor I, Inactive Control
InChI key
WRDKBSLEHFRKGG-UHFFFAOYSA-N
InChI
1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Sirtuin 3
Sirtuin 3
Product does not compete with ATP.
Reversible: no
Target IC50: >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2
Packaging
Packaged under inert gas
Other Notes
Outerio, T.F., et al. 2007. Science317, 516.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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