566326
SIRT2 Inhibitor, Inactive Control, AGK7
The SIRT2 Inhibitor, Inactive Control, AGK7, also referenced under CAS 304896-21-7, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
SIRT2 Inhibitor, Inactive Control, AGK7, SIRT2 Inhibitor I, Inactive Control
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About This Item
质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)
InChI key
WRDKBSLEHFRKGG-UHFFFAOYSA-N
一般描述
A cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.
生化/生理作用
Cell permeable: yes
Primary Target
Sirtuin 3
Sirtuin 3
Product does not compete with ATP.
Reversible: no
Target IC50: >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2
包装
Packaged under inert gas
警告
Toxicity: Regulatory Review (Z)
其他说明
Outerio, T.F., et al. 2007. Science317, 516.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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