567417
SOD1抑制剂，LCS-1
The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1.
别名:
SOD1抑制剂，LCS-1
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关于此项目
经验公式（希尔记法）:
C11H8Cl2N2O
化学文摘社编号:
分子量:
255.10
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
产品名称
SOD1抑制剂，LCS-1, The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1.
SMILES string
ClC1=C(C(=O)N(N=C1)c2cc(ccc2)C)Cl
InChI
1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3
InChI key
SYUPLLHVMCLXEM-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
Disclaimer
毒性：标准处理（A）
General description
一种2-苯基哒嗪-3（2H）-酮基非铜螯合剂，可选择性抑制超氧化物歧化酶1（Cu/Zn-SOD）的活性（IC50=1.07 µM）。过度表达SOD1的细胞对LCS-1的敏感性降低。显示出更好地抑制具有EGFR和KRAS突变（IC50=200 nM）的多种人类肺腺癌细胞系的生长。阻止血清诱导的ERK和PI 3激酶/AKT信号的激活，从而影响细胞生长和存活。据报道，该化合物在人肝微粒体中的表观半衰期为6.6分钟。
Other Notes
Somwar, R., et al. 2011, PNAS in press.
Somwar, R., et al. 2009.J. Biomol.Screen14, 1176
Somwar, R., et al. 2009.J. Biomol.Screen14, 1176
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Min Ling et al.
Frontiers in oncology, 12, 937444-937444 (2022-08-19)
Gliomas are characterized by high morbidity and mortality, and have only slightly increased survival with recent considerable improvements for treatment. An innovative therapeutic strategy had been developed via inducing ROS-dependent cell death by targeting antioxidant proteins. In this study, we
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