SMILES string
[Cl-].[Cl-].[Cl-].[Cl-].[N+H2](CCC[N+H3])CCCC[N+H2]CCC[N+H3]
InChI
1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChI key
XLDKUDAXZWHPFH-UHFFFAOYSA-N
description
RTECS - EJ7230000
Merck USA index - 14, 8743
assay
≥99% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 20 mg/mL
shipped in
ambient
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
Primary Target
phospholipase C α
phospholipase C α
Secondary Target
nNOS
nNOS
Disclaimer
Toxicity: Irritant (B)
General description
Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.
Other Notes
Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J.8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int.32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem.124, 141.
Ask, A., et al. 1992. Cancer Lett.66, 29.
Chida, N., et al. 1992. Brain Res.593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys.297, 328.
Shantz, L.M., et al. 1992. Biochem. J.288, 511.
Escargueil-Blanc, I., et al. 1994. FASEB J.8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int.32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem.124, 141.
Ask, A., et al. 1992. Cancer Lett.66, 29.
Chida, N., et al. 1992. Brain Res.593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys.297, 328.
Shantz, L.M., et al. 1992. Biochem. J.288, 511.
Preparation Note
Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Stanislau Yatskevich et al.
Cell reports, 34(13), 108929-108929 (2021-04-01)
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle transitions. Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic spindle. APC/C SUMOylation on APC4 ensures timely
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