567732
Sphingosine Kinase 1 Inhibitor, SKI-178
别名:
Sphingosine Kinase 1 Inhibitor, SKI-178, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
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关于此项目
经验公式（希尔记法）:
C21H22N4O4
分子量:
394.42
NACRES:
NA.28
UNSPSC Code:
12352200
Assay:
≥92% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze
protect from light
protect from light
assay
≥92% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).
Other Notes
Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Rui Sun et al.
Cell reports, 38(13), 110560-110560 (2022-03-31)
It is not clear how the complex interactions between diet and intestinal immune cells protect the gut from infection. Neutral ceramidase (NcDase) plays a critical role in digesting dietary sphingolipids. We find that NcDase is an essential factor that controls
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