572201
链脲佐菌素
An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.
别名:
链脲佐菌素
SMILES string
N(N=O)(C)C(=O)N[C@H]1[C@H](O[C@@H]([C@H]([C@@H]1O)O)CO)O
InChI
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChI key
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
assay
≥95% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white to pale yellow
solubility
water: soluble
cation traces
heavy metals: ≤5 ppm
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
含 N-亚硝基的促糖尿病化合物，在胰岛中充当一氧化氮供体。一种对革兰氏阴性细菌有效的抗生素。在胰腺胰岛细胞中引起 DNA 烷基化和 DNA 链断裂。
含 N-亚硝基的化合物，在胰岛中充当一氧化氮的供体。一种对革兰氏阴性细菌有效的抗生素。在胰腺胰岛细胞中引起 DNA 烷基化和 DNA 链断裂。致糖尿病剂。
Preparation Note
溶液中不稳定；仅在使用前进行重悬。初次融化后，等分并冷冻（-20°C）。
Other Notes
Kroncke, K.D., et al. 1995.Biol. Chem. Hoppe Seyler376, 179.
Kwon, N.S., et al. 1994.FASEB J.8, 529.
Rasschaert, J., et al. 1992.Endocrinology130, 3522.
Bennett, R.A. and Pegg, A.E.1981.Cancer Res.41, 2786.
Adams, J., et al. 1981.Nature294, 284.
Kwon, N.S., et al. 1994.FASEB J.8, 529.
Rasschaert, J., et al. 1992.Endocrinology130, 3522.
Bennett, R.A. and Pegg, A.E.1981.Cancer Res.41, 2786.
Adams, J., et al. 1981.Nature294, 284.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害 & 致癌/致畸性（E）
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Flam. Sol. 1 - Muta. 2
存储类别
4.1B - Flammable solid hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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