572636
InSolution SU6656-Calbiochem
InSolution, ≥95%, inhibitor of Src-family protein tyrosine kinases
别名:
InSolution SU6656
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
Quality Level
相关类别
General description
A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC50 >10 µM) and IGF-1 receptor kinase (IC50 gt;20 µM).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 280 nM inhibiting Src
Packaging
Packaged under inert gas
Physical form
A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572635) in DMSO.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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