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Merck
CN

573099

Stattic

≥95% (HPLC), STAT3 inhibitor, solid

别名:

STAT3抑制剂V，Stattic

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关于此项目

经验公式（希尔记法）:
C8H5NO4S
化学文摘社编号:
19983-44-9
分子量:
211.19
MDL编号:
MFCD00173799
UNSPSC代码:
12352200
NACRES:
NA.77

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产品名称

STAT3抑制剂V，Stattic, STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

质量水平

100

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

pale yellow

溶解性

DMSO: 10 mg/mL
ethanol: 5 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[S]1(=O)(=O)c2c(ccc(c2)[N+](=O)[O-])C=C1

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChI key

ZRRGOUHITGRLBA-UHFFFAOYSA-N

相关类别

一般描述

一种细胞渗透性乙烯基砜化合物，通过靶向STAT3-SH2结构域并阻止其与上游激酶结合，作为STAT3细胞功能的抑制剂。Stattic对STAT家族成员的影响取决于温度，在37°C时似乎具有高度的STAT3选择性。显示抑制STAT3在Tyr705位的细胞磷酸化，对Tyr701处的STAT1磷酸化（在HepG2细胞中）或JAK1、JAK2和c-Src的磷酸化（在MDA-MB-231和MDA-MB-235S细胞中）几乎没有影响。

生化/生理作用

主靶
STAT3
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

包装

用惰性气体包装

制备说明

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多1个月。注意：强烈建议使用新开的DMSO；DMSO中存在的硫醇杂质将修饰分子。强烈建议在每次使用前复溶。

其他说明

Schust, J., et al. 2006.Chem. Biol.13, 1235.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：刺激性（B）

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Pathways and Biomarkers of JAK/STAT Signaling

Pathways and Biomarkers of JAK/STAT Signaling

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

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