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Merck
CN

573102

S3I-201

≥95% (HPLC), solid, STAT3 inhibitor, Calbiochem®

别名:

STAT3抑制剂VI，S3I-201

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关于此项目

经验公式（希尔记法）:
C16H15NO7S
化学文摘社编号:
501919-59-1
分子量:
365.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09907564
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
protect from light

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产品名称

STAT3抑制剂VI，S3I-201, STAT3 Inhibitor VI, S3I-201, CAS 501919-59-1, is a cell-permeable compound that binds Stat3-SH2 domain and blocks Stat3 phosphorylation, dimerization, DNA-binding, & Stat3-dependent transcription.

Quality Level

100

SMILES string

[S](=O)(=O)(OCC(=O)Nc2cc(c(cc2)C(=O)O)O)c1ccc(cc1)C

InChI

1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

InChI key

HWNUSGNZBAISFM-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light beige

solubility

DMSO: 10 mg/mL (Use only fresh, anhydrous DMSO.)

shipped in

ambient

storage temp.

−20°C

相关类别

Disclaimer

毒性：监管审查（Z）

General description

一种细胞渗透性氨基水杨酸化合物，可结合Stat3-SH2结构域并阻止Stat3磷酸化/激活、二聚化、DNA结合和Stat3依赖性转录。显示在体外培养（有效浓度≤100 µM）和体内鼠异种移植模型（5 mg/kg，i.v.）中抑制Stat3依赖性肿瘤生长。也可以50 mM的DMSO溶液（目录号573130）提供。

Packaging

用惰性气体包装

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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International Journal of Molecular Sciences, 24 (2023)
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Compensatory growth of organs after loss of their mass and/or function is controlled by hepatocyte growth factor (HGF), but the underlying regulatory mechanisms remain elusive. Here, we show that CUB domain-containing protein 1 (CDCP1) promotes HGF-induced compensatory renal growth. Using

相关内容

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

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