573126
STAT3 Inhibitor XI, STX-0119
The STAT3 Inhibitor XI, STX-0119 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
STAT3 Inhibitor XI, STX-0119, N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide
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关于此项目
经验公式（希尔记法）:
C22H14N4O3
化学文摘社编号:
分子量:
382.37
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
protect from light, OK to freeze
Quality Segment
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
protect from light, OK to freeze
color
gray to off-white
solubility
DMSO: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(NC1=NN=C(C2=CC=CO2)O1)C3=CC(C4=CC=CC=C4)=NC5=C3C=CC=C5
InChI key
MNPXTRXFUMGQLK-UHFFFAOYSA-N
General description
A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity in nuclear extract from IL-6-stimulated MDA-MB-468 cells (by 74% at 50 µM) and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 50% and 99%, respectively, at 74 and 100 µM), as well as inhibit the expression of STAT3 target genes, c-myc, cyclin D1, and survivin, both in cultures in vitro (effective conc. 50 µM) and in SCC3-derived tumors in mice in vivo (160 mg/kg/day; p.o.).
Packaging
Packaged under inert gas
Other Notes
Ashizawa, T., et al. 2011. Int. J. Oncol.38, 1245,
Matsuno, K., et al. 2010. ACS Med. Chem. Lett.1, 371.
Matsuno, K., et al. 2010. ACS Med. Chem. Lett.1, 371.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable