574713
Syk Inhibitor III
The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Syk Inhibitor III, 3,4-Methylenedioxy-β-nitrostyrene
描述
RTECS - WL5270000
质量水平
方案
≥98% (GC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow to brown
溶解性
DMSO: 25 mg/mL (Use only fresh DMSO.)
运输
ambient
储存温度
−20°C
SMILES字符串
[N+](=O)([O-])\C=C/c1cc2c(cc1)OCO2
InChI
1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
InChI key
KFLWBZPSJQPRDD-ARJAWSKDSA-N
相关类别
一般描述
A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).
生化/生理作用
Cell permeable: yes
Primary Target
Syk
Syk
Product does not compete with ATP.
Reversible: no
Target IC50: 2.5 µM against Syk kinase activity
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Irritant (B)
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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