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About This Item
经验公式（希尔记法）:
C20H18N6O3 · xHCl · yH2O
CAS Number:
分子量:
390.40 (anhydrous free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
Product Name
Syk Inhibitor IV, BAY 61-3606, The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
质量水平
方案
≥97% (HPLC)
表单
solid
效能
10 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
yellow
溶解性
DMSO: 10 mg/mL
water: 20 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
[n]21c(ncc2)cc(nc1Nc4ncccc4C(=O)N)c3cc(c(cc3)OC)OC
InChI
1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
InChI key
JWQOJVOKBAAAAR-UHFFFAOYSA-N
相关类别
一般描述
A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
生化/生理作用
Cell permeable: yes
Primary Target
Syk
Syk
Product competes with ATP.
Reversible: yes
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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