574715
Syk Inhibitor V
The Syk Inhibitor V controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Syk Inhibitor V, (S)-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor
质量水平
方案
≥99% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 50 mg/mL, pale yellow
运输
ambient
储存温度
−20°C
SMILES字符串
CC1=CC(C)=CC(NC2=NC=CC(C3=NC(C)=C(C(N[C@@H](C)CO)=O)S3)=N2)=C1
一般描述
A cell-permeable 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (Ki = 9nM). Exhibits excellent selectivity over Cdk2 (Ki ≥ 3.33 µM); ROCK Ki = 2.3 µM), Src Ki ≥ 3.33 µM) and ZAP 70 (Ki = 240 nM). Shown to inhibit mast cell degranulation (IC50 = 70 nM) that is commonly observed in asthma and other allergic diseases.
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°c.
其他说明
Farmer, L., et al. 2008. Bioorg. Med. Chem. Lett.18, 6231.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Regulatory Review (Z)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Priyanka Ramesh et al.
Pharmaceutics, 13(11) (2021-11-28)
Rearranged during transfection (RET) is a tyrosine kinase oncogenic receptor, activated in several cancers including non-small-cell lung cancer (NSCLC). Multiple kinase inhibitors vandetanib and cabozantinib are commonly used in the treatment of RET-positive NSCLC. However, specificity, toxicity, and reduced efficacy
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