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579000

Tamoxifen Citrate

Name: Tamoxifen Citrate
Brand: MM

Tamoxifen is a potent synthetic anti-estrogenic agent.

别名:

Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I

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About This Item

经验公式（希尔记法）:

C₂₆H₂₉NO · xC₆H₈O₇

CAS Number:

54965-24-1

分子量:

371.51 (salt-free basis)

MDL编号:

MFCD00058321

UNSPSC代码:

12352200

NACRES:

NA.77

描述

Merck USA index - 14, 9048

质量水平

100

方案

≥99% (HPLC)

表单

powder

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze

颜色

white to off-white

溶解性

ethanol: 5 mg/mL
methanol: 5 mg/mL
water: sparingly soluble

运输

ambient

储存温度

2-8°C

SMILES字符串

N(CCOc1ccc(cc1)\C(=C(\CC)/c3ccccc3)\c2ccccc2)(C)C.[O-]C(=O)C(O)(CC(=O)[O-])CC(=O)[O-].[H+].[H+].[H+]

InChI

1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

InChI key

FQZYTYWMLGAPFJ-OQKDUQJOSA-N

一般描述

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines.

A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

生化/生理作用

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 10 µM against protein kinase C

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

GHS08,GHS07,GHS09

警示用语：

Danger

危险声明

H302,H350,H360D,H410

预防措施声明

P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)