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Merck
CN

579000

Sigma-Aldrich

Tamoxifen Citrate

≥99% (HPLC), Estrogen receptor modulator, powder

别名:

Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I

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关于此项目

经验公式（希尔记法）:
C26H29NO · xC6H8O7
CAS Number:
54965-24-1
分子量:
371.51 (salt-free basis)
MDL编号:
MFCD00058321
UNSPSC代码:
12352200
NACRES:
NA.77

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Product Name

Tamoxifen Citrate, Tamoxifen is a potent synthetic anti-estrogenic agent.

描述

Merck USA index - 14, 9048

质量水平

100

方案

≥99% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white to off-white

溶解性

ethanol: 5 mg/mL
methanol: 5 mg/mL
water: sparingly soluble

运输

ambient

储存温度

2-8°C

SMILES字符串

N(CCOc1ccc(cc1)\C(=C(\CC)/c3ccccc3)\c2ccccc2)(C)C.[O-]C(=O)C(O)(CC(=O)[O-])CC(=O)[O-].[H+].[H+].[H+]

InChI

1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

InChI key

FQZYTYWMLGAPFJ-OQKDUQJOSA-N

一般描述

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines.
A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

生化/生理作用

Cell permeable: yes
Primary Target
PKC
Product does not compete with ATP.
Reversible: yes
Target IC50: 10 µM against protein kinase C

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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