Merck
CN
所有图片(1)

文件

安全信息

579000

Sigma-Aldrich

Tamoxifen Citrate

Tamoxifen is a potent synthetic anti-estrogenic agent.

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别名:
Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I
经验公式（希尔记法）:
C26H29NO · xC6H8O7
CAS号:
54965-24-1
分子量:
371.51 (salt-free basis)
MDL编号:
MFCD00058321

质量水平

100

检测方案

≥99% (HPLC)

形式

powder

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze

颜色

white to off-white

溶解性

ethanol: 5 mg/mL
methanol: 5 mg/mL
water: sparingly soluble

运输

ambient

储存温度

2-8°C

InChI

1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

InChI key

FQZYTYWMLGAPFJ-OQKDUQJOSA-N

一般描述

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines.
A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

生化/生理作用

Cell permeable: yes
Primary Target
PKC
Product does not compete with ATP.
Reversible: yes
Target IC50: 10 µM against protein kinase C

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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