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Merck
CN

579000

Tamoxifen Citrate

≥99% (HPLC), Estrogen receptor modulator, powder

别名:

Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I

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关于此项目

经验公式（希尔记法）:
C26H29NO · xC6H8O7
化学文摘社编号:
54965-24-1
分子量:
371.51 (salt-free basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00058321

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产品名称

Tamoxifen Citrate, Tamoxifen is a potent synthetic anti-estrogenic agent.

SMILES string

N(CCOc1ccc(cc1)\C(=C(\CC)/c3ccccc3)\c2ccccc2)(C)C.[O-]C(=O)C(O)(CC(=O)[O-])CC(=O)[O-].[H+].[H+].[H+]

InChI

1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

InChI key

FQZYTYWMLGAPFJ-OQKDUQJOSA-N

description

Merck USA index - 14, 9048

assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

ethanol: 5 mg/mL
methanol: 5 mg/mL
water: sparingly soluble

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKC
Product does not compete with ATP.
Reversible: yes
Target IC50: 10 µM against protein kinase C

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

General description

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines.
A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

Other Notes

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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