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Merck
CN

579002

(Z)-4-Hydroxytamoxifen

≥99% (HPLC), solid, estrogen receptor modulator, Calbiochem

别名:

(Z)-4-羟基-三苯氧胺，大包装, (Z)-4-羟基他莫昔芬，4-OH-TAM，雌激素受体信号调节剂II

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关于此项目

经验公式（希尔记法）:
C26H29NO2
化学文摘社编号:
68047-06-3
分子量:
387.51
MDL编号:
MFCD00278780
UNSPSC代码:
12352200
NACRES:
NA.77

主要文件

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产品名称

(Z)-4-羟基-三苯氧胺，大包装, A cell-permeable, active metabolite of Tamoxifen that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

质量水平

200

方案

≥99% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

methanol: 10 mg/mL
ethanol: 20 mg/mL (heating may be required)

运输

ambient

储存温度

2-8°C

InChI

1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key

DODQJNMQWMSYGS-QPLCGJKRSA-N

相关类别

一般描述

三苯氧胺的一种细胞渗透性活性代谢物（目录号579000），作为PKC的有效抑制剂。它比母体化合物更有效，并通过修饰 PKC 的催化结构域抑制 PKC。也可以10 mM的EtOH溶液（目录号508225）提供。

生化/生理作用

主要靶标
PKC
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

制备说明

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

其他说明

Gundimeda, U., et al. 1996.J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J.1996.Carcinogenesis 17, 1747.
Laser, R., et al. 1985.Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978.J. Toxicol.Environ.Health 4, 364.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

毒性：有害 & 致癌/致畸性（E）

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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