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Merck
CN

579002

(Z)-4-Hydroxytamoxifen

≥99% (HPLC), solid, estrogen receptor modulator, Calbiochem

别名:

(Z)-4-羟基-三苯氧胺，大包装, (Z)-4-羟基他莫昔芬，4-OH-TAM，雌激素受体信号调节剂II

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关于此项目

经验公式（希尔记法）:
C26H29NO2
化学文摘社编号:
68047-06-3
分子量:
387.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00278780

主要文件

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产品名称

(Z)-4-羟基-三苯氧胺，大包装, A cell-permeable, active metabolite of Tamoxifen that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

InChI

1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key

DODQJNMQWMSYGS-QPLCGJKRSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

methanol: 10 mg/mL, ethanol: 20 mg/mL (heating may be required)

shipped in

ambient

Quality Level

200

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相关类别

General description

三苯氧胺的一种细胞渗透性活性代谢物（目录号579000），作为PKC的有效抑制剂。它比母体化合物更有效，并通过修饰 PKC 的催化结构域抑制 PKC。也可以10 mM的EtOH溶液（目录号508225）提供。

Biochem/physiol Actions

主要靶标
PKC
产物不与ATP竞争。
可逆：否
细胞可渗透性：是

Preparation Note

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

Other Notes

Gundimeda, U., et al. 1996.J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J.1996.Carcinogenesis 17, 1747.
Laser, R., et al. 1985.Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978.J. Toxicol.Environ.Health 4, 364.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：有害 & 致癌/致畸性（E）

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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