579052
TAPI-2
TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.
别名:
TAPI-2, N-(R)-[2-(羟基氨基羰基)甲基]-4-甲基戊酰基-L-叔-丁基-丙氨酰-L-丙氨酸，2-氨基乙基酰胺，TNF-α蛋白酶抑制剂-2
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关于此项目
经验公式（希尔记法）:
C19H37N5O5
化学文摘社编号:
分子量:
415.53
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
ethanol: 5 mg/mL, water: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
一种基于异羟肟酸的基质金属蛋白酶和TACE（TNF-α转化酶；ADAM17）抑制剂。抑制中性粒细胞、嗜酸性粒细胞和淋巴细胞L-选择素的活化依赖性脱落，以及苯胂氧化物（PAO）诱导的中性粒细胞脱落。还可阻止多种细胞表面蛋白的脱落，如前TGF-α、IL-6受体α-亚单位和淀粉-β样前体蛋白。据报道可抑制TNF-α的释放，并对阿司匹林引起的胃粘膜损伤具有保护作用。作为血管紧张素转换酶的弱抑制剂（IC50=18µM）。
Biochem/physiol Actions
主要靶标
MMPs
MMPs
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
靶标IC50：血管紧张素转换酶为18 µM
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Bennett, T.A., et al. 2000.J. Immunol.164, 4120.
Fiorucci, S., et al. 1998.Aliment.Pharmacol.Ther.12, 1139.
Hooper, N.M., et al. 1997.Biochem.J.321, 265.
Parvathy, S., et al. 1997.Biochem.J. 327, 37.
Arribas, J., et al. 1996.J. Biol. Chem.271, 11376.
Fiorucci, S., et al. 1998.Aliment.Pharmacol.Ther.12, 1139.
Hooper, N.M., et al. 1997.Biochem.J.321, 265.
Parvathy, S., et al. 1997.Biochem.J. 327, 37.
Arribas, J., et al. 1996.J. Biol. Chem.271, 11376.
Legal Information
由Peptides International, Louisville, Kentucky, USA独家生产。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable