580549
牛磺酸去氧胆酸，钠盐
Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.
别名:
牛磺酸去氧胆酸，钠盐, 牛磺熊脱氧胆酸钠
描述
RTECS - KI7372500
质量水平
方案
≥97% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
water: 100 mg/mL
运输
ambient
储存温度
15-25°C
SMILES字符串
[S](=O)(=O)(O)CCNC(=O)CC[C@H]([C@@H]1[C@@]2(C(C3[C@H](C[C@H]4[C@@](C3CC2)(CC[C@H](C4)O)C)O)CC1)C)C
InChI
1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,22+,24?,25+,26-/m1/s1
InChI key
BHTRKEVKTKCXOH-AYSJQVDDSA-N
一般描述
用于溶解脂质和膜结合蛋白质的洗涤剂。对大鼠体内的疏水性胆盐具有冷冻保护作用。据报道也可抑制体外胃蛋白酶活性。
应用
- 内质网应激的抑制以及血管紧张素转换酶2的激活：预防1型糖尿病大鼠内皮功能障碍的新方法: 本研究的亮点是牛磺脱氧胆酸钠减少内质网应激的功效，表明其在预防糖尿病血管并发症方面的实用性((Gaikwad AB et al., 2022)。
其他说明
Ozcan, U., et al. 2006.Science313, 1137.
Miyake, H., et al. 1999.Dig.Dis.Sci.44, 197.
Eto, T. and Tompkins, R.K.1985.Am. J. Surg.150, 564.
Miyake, H., et al. 1999.Dig.Dis.Sci.44, 197.
Eto, T. and Tompkins, R.K.1985.Am. J. Surg.150, 564.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Hongchun Zhao et al.
Frontiers in genetics, 11, 495-495 (2020-06-17)
Endoplasmic reticulum (ER) stress occurs in many inflammatory responses. Here, we investigated the role of ER stress and its associated apoptosis in otitis media (OM) to elucidate the mechanisms of OM and the signaling crosstalk between ER stress and other
Maddalena Parafati et al.
Disease models & mechanisms, 11(9) (2018-09-27)
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stress response and hepatocyte metabolism disorders prompted
Isabel Castro et al.
Rheumatology (Oxford, England), 59(4), 742-753 (2019-08-05)
Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin
Ihab H Hassan et al.
The Journal of biological chemistry, 287(7), 4679-4689 (2011-12-24)
Known therapies for influenza A virus infection are complicated by the frequent emergence of resistance. A therapeutic strategy that may escape viral resistance is targeting host cellular mechanisms involved in viral replication and pathogenesis. The endoplasmic reticulum (ER) stress response
Per Flodby et al.
American journal of respiratory cell and molecular biology, 55(1), 135-149 (2016-01-28)
Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, has been linked to endoplasmic reticulum (ER) stress. To investigate a causal role for ER stress in BPD pathogenesis, we generated conditional knockout (KO) mice (cGrp78(f/f)) with lung epithelial cell-specific KO
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