581004
Telomerase Inhibitor III, Sodium Salt
The Telomerase Inhibitor III, Sodium Salt controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
TAG-6, 5ʹ-d(TTAGGG)-3ʹ
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
water: soluble
shipped in
wet ice
storage temp.
−70°C
Quality Level
General description
A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomere mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM. Note: 150 nmol = 285 µg.
M.W. ~1900.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Telomerase activity in cell lysates
Telomerase activity in cell lysates
Product competes with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
5′-d(TTAGGG)-3′
Mata, J.E., et al. 1997. Toxicol. Appl. Pharmacol. 144, 189.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Manuel Bernabé-García et al.
Molecular oncology, 15(7), 1818-1834 (2021-03-14)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere-independent functions of human TERT have been described. In this study, we report that TERT binds directly to the TCF binding elements located
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