产品名称
破伤风类毒素，来源于破伤风梭菌, This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
Quality Segment
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
soluble (Reconstitute in 50 µl of sterile distilled H2O)
shipped in
ambient
storage temp.
2-8°C
General description
破伤风类毒素属于疫苗类药物。适用于破伤风免疫和伤口预防。根据小鼠LD50测定，无毒。
Application
Biochem/physiol Actions
破伤风类毒素对破伤风梭菌起作用，破伤风梭菌是一种革兰氏阳性杆菌，能产生一种叫做破伤风痉挛蛋白的神经毒素。破伤风痉挛素阻止一种抑制性神经递质的释放，引起非对抗性肌肉收缩和痉挛。破伤风类毒素疫苗刺激免疫系统对疫苗抗原作出反应。免疫系统t淋巴细胞（TH2和B细胞）分泌免疫球蛋白对抗疫苗中的抗原。这种免疫球蛋白有助于预防未来的感染。
Features and Benefits
- 通过甲醛灭活破伤风毒素制备而成。
- 通过甲醛灭活破伤风毒素制备而成。
- 类毒素保留了其抗原性，但根据对小鼠的半数致死剂量测定，基本上是无毒的。
- 细胞渗透性：无
- 产品不与 ATP 竞争。
- 可逆性：否
Physical form
由 100 mM 组氨酸、100 mM NaCl、5% 海藻糖、pH 7.0 冻干而成。
Preparation Note
在50µl无菌H₂O水中复溶
Other Notes
Wrenger, S., et al. 2000.J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985.In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.)Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981.J. Immunol.127, 1275.
Bizzini, B., et al. 1970.Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J.1956.Biochem.Biophys.Acta20, 407.
Habermann E. and Goretzki, K. 1985.In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.)Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981.J. Immunol.127, 1275.
Bizzini, B., et al. 1970.Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J.1956.Biochem.Biophys.Acta20, 407.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
怎么回事？
WGK 1
闪点 (F)
Not applicable
闪点 (°C)
Not applicable