Tetanus Toxin, C-Fragment, Clostridium tetani

The C-terminal binding portion of the chain of tetanus toxin. The intact toxin is known to block neurotransmitter release at inhibitory synapses in cultured spinal cord cells. Shows trans-synaptic retrograde transport in the central nervous system. Caution: may contain trace amounts of intact toxin. Follow the handling procedure described in the information that accompanies the product.

The C-terminal binding portion of the heavy chain of tetanus toxin.

Primary Target
Useful for binding studies

Product does not compete with ATP.

Lyophilized from 10 mM sodium phosphate buffer, pH 7.5.

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Once an aliquot has been thawed, do not refreeze. Aqueous stock solutions are stable for 7-10 days at 4°C.

Single major band by SDS-PAGE

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Poulain, B. 1994. Pathol. Biol. 42, 173.
Williamson, L.C., et. al. 1993. Soc. Neurosci. 19, Abstract 770.10.
Evinger, C. and Erichsen, J.T. 1986. Brain Res.380, 383.
Helting, T.B. and Zwisler, O. 1977. J. Biol. Chem.252, 187.
Matsuda, M. and Yoneda, M. 1977. Biochem. Biophys. Res. Commun.77, 268.

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Toxicity: Highly Toxic (H)