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Merck
CN

598226

硫链丝菌素

≥98% (HPLC), powder, FOXM1 inhibitor, Calbiochem®

别名:

硫链丝菌素, FOXM1抑制剂I

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关于此项目

经验公式（希尔记法）:
C72H85N19O18S5
化学文摘社编号:
1393-48-2
分子量:
1664.89
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00135828

主要文件

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产品名称

硫链丝菌素, Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.

InChI

1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15+

InChI key

NSFFHOGKXHRQEW-DVRIZHICSA-N

description

Merck USA index - 14, 9364

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

off-white

solubility

DMSO: 10 mg/mL
chloroform: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要靶标
EF-G

Disclaimer

毒性：标准处理（A）

General description

一种从链霉菌属远青链霉菌中分离出来的含噻唑多肽抗生素。通过与50S亚基GTPase中心的23S rRNA非共价，但几乎不可逆地结合，抑制细菌蛋白质合成和核糖体GTPase活性。硫链丝菌素结合直接阻止与延伸因子G（EF-G）核糖体的结合，延伸因子G也与23S rRNA特异性结合。硫链丝菌素已被证明在阐明翻译的分子机制，特别是核糖体易位的分子机制方面很有用。它还用于在链霉菌属细菌中选择含有tsr基因（蓝色链霉菌）的载体，该基因编码23S rRNA甲基化酶，其作用阻止硫链丝菌素与核糖体结合。
一种含噻唑的肽抗生素，通过阻止GTP与50S核糖体亚单位的结合来抑制蛋白质合成。抑制延伸因子G（EF-G）的功能和EF-G与核糖体的分离。抗硫链菌素基因也常用作重组DNA/质粒技术的选择标记。

Other Notes

Rodnina, M.V., et al. 1999.Proc.Natl.Acad.Sci USA96, 9586.
Rosendahl, G. and Douthwaite, S. 1994.Nucleic Acids Res.22, 357.
Saarma, U. and Remme, J. 1992.Nucleic Acids Res.20, 3147.
Malina, H. and Robert-Gero, M. 1992.Appl. Environ.Microbiol.58, 895.
Blanco, G., et al. 1992.Gene112, 59.
Miller, S.P. and Bodley, J.W.1991.Nucleic Acids Res.19, 1657.
Ryan, P.C., et al. 1991.J. Mol.Biol.221, 1257.
Kutay, U.R., et al. 1990.Biochim.Biophys.Acta1050, 193.
Smokvina, T., et al. 1990.Gene94, 53.
Garrett, R. 1983.Trends Biochem.Sci.8, 189.
Bodley, J.W., et al. 1970.Biochem.Biophys.Res. Commun.41, 1406.
Thompson, J. and Cundliffe, E. 1970.Biochimie 73, 1131.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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