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Merck
CN

605208

Thrombin Receptor Agonist

The Thrombin Receptor Agonist, also referenced under CAS 137339-65-2, controls the biological activity of Thrombin Receptor. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

别名:

Thrombin Receptor Agonist

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关于此项目

化学文摘社编号:
137339-65-2
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00133815

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SMILES string

N4([C@@H](CCC4)C(=O)N[C@@H](Cc5ccccc5)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CO)Cc3ccccc3)CC(C)C)CC(C)C)CCCN\C(=N\[H])\N)CC(=

InChI

1S/C81H118N20O23/c1-43(2)34-53(93-71(114)54(35-44(3)4)94-73(116)55(92-67(110)49(83)42-102)36-45-16-7-5-8-17-45)70(113)90-51(21-13-31-88-81(86)87)69(112)98-59(40-64(85)105)79(122)101-33-15-22-61(101)76(119)97-57(39-63(84)104)74(117)96-58(41-66(108)109)75(118)89-50(20-11-12-30-82)68(111)95-56(37-47-24-26-48(103)27-25-47)72(115)91-52(28-29-65(106)107)78(121)100-32-14-23-62(100)77(120)99-60(80(123)124)38-46-18-9-6-10-19-46/h5-10,16-19,24-27,43-44,49-62,102-103H,11-15,20-23,28-42,82-83H2,1-4H3,(H2,84,104)(H2,85,105)(H,89,118)(H,90,113)(H,91,115)(H,92,110)(H,93,114)(H,94,116)(H,95,111)(H,96,117)(H,97,119)(H,98,112)(H,99,120)(H,106,107)(H,108,109)(H,123,124)(H4,86,87,88)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1

InChI key

OXHYRVSBKWIFES-WWSDOYNLSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

5% acetic acid: 1 mg/mL, water: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

Potent agonist for thrombin receptor activation. Induces platelet aggregation.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Thrombin Receptor
Product does not compete with ATP.
Reversible: no

Packaging

Yes

Physical form

Supplied as trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C).

Other Notes

H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH
Sabo, T., et al. 1992. Biochem. Biophys. Res. Commun. 188, 604.
Ngaiza, J.R. and Jaffe, E.A. 1991. Biochem. Biophys. Res. Commun.179, 1057.
Vu, T.K.H., et al. 1991. Cell64, 1057.
Vu, T.K.H., et al. 1991. Nature353, 674.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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