613551
TMEM16A Inhibitor, T16Ainh-A01
The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.
别名:
TMEM16A Inhibitor, T16Ainh-A01, ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
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关于此项目
经验公式（希尔记法）:
C19H20N4O3S2
化学文摘社编号:
分子量:
416.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mg/mL, clear, colorless
shipped in
ambient
storage temp.
2-8°C
SMILES string
[s]1c(nc(c1)c3ccc(cc3)OC)NC(=O)CSc2[nH][c](c(c(n2)C)CC)=O
InChI
1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
InChI key
QSIYTNYMBWYHAA-UHFFFAOYSA-N
General description
An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547 ) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Davis, A.J., et al. 2012 Br. J. Pharmacol.,in press
Namkung, W., et al. 2011., J Biol Chem. in press.
Namkung, W., et al. 2011., FASEB J. in press.
Namkung, W., et al. 2011., J Biol Chem. in press.
Namkung, W., et al. 2011., FASEB J. in press.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
flash_point_f
Not applicable
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_c
Not applicable