614310
TLR3/dsRNA复合物抑制剂
≥99% (HPLC), solid, TLR3/dsRNA complex inhibitor, Calbiochem®
别名:
TLR3/dsRNA复合物抑制剂, (R)-2-(3-氯-6-氟苯并[b]噻吩-2-甲酰胺基）-3-苯基丙酸，Toll样受体3 /双链RNA复合物抑制剂
Product Name
TLR3/dsRNA复合物抑制剂, The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.
质量水平
方案
≥99% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
运输
wet ice
储存温度
2-8°C
相关类别
一般描述
噻吩甲酰胺基丙酸酯化合物可作为直接竞争性和高亲和力抑制剂，抑制dsRNA和TLR3的结合（Ki = 2.96 µM；dsRNA结合TLR3的Kd = 19 nM），同时其可选择性拮抗经刺激的TLR3信号转导，且不会影响TLR1/2、TLR2/6、TLR4和TLR7途径。在Poly（I：C）诱导的RAW 264.7巨噬细胞中，其显示出可有效抑制TNF-α和IL-1β（IC90 = 27 µM）和NO的产生（IC50 = 3.44 µM）。其表现出最小的细胞毒性（在RAW 264.7细胞中IC50 >>100 µM），并对一组12种代表性激酶和4种细胞色素酶的活性有较弱的抑制作用（体外分析）。
包装
用惰性气体包装
其他说明
Cheng, K., et al. 2011.J. Am. Chem. Soc.133, 3764.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：标准处理（A）
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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