Topoisomerase II Inhibitor, BNS-22

Name: Topoisomerase II Inhibitor, BNS-22
Brand: MM

The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

Topoisomerase II Inhibitor, BNS-22, BNS-22

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经验公式（希尔记法）:

C₂₄H₂₅NO₅

分子量:

407.46

UNSPSC Code:

12352200

NACRES:

NA.54

MDL number:

MFCD22628799

主要文件

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产品名称

Topoisomerase II Inhibitor, BNS-22, The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

SMILES string

N3(CCCc4c3cccc4)C(=O)c1c2c(c(cc1OC)OC)C(=CC(=O)O2)CCC

InChI

1S/C24H25NO5/c1-4-8-16-13-20(26)30-23-21(16)18(28-2)14-19(29-3)22(23)24(27)25-12-7-10-15-9-5-6-11-17(15)25/h5-6,9,11,13-14H,4,7-8,10,12H2,1-3H3

InChI key

LRPUQCTZOSTSGL-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 25 mg/mL, clear, colorless

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC₅₀ = 2.8 µM and 0.42 µM for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.

Other Notes

Kawatani, M., et al. 2011. Chem Biol.18, 743.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis.

Arun Pal et al.

Life science alliance, 4(4) (2021-02-24)

Intronic hexanucleotide repeat expansions (HREs) in C9ORF72 are the most frequent genetic cause of amyotrophic lateral sclerosis, a devastating, incurable motoneuron (MN) disease. The mechanism by which HREs trigger pathogenesis remains elusive. The discovery of repeat-associated non-ATG (RAN) translation of

Topoisomerase II Inhibitor, BNS-22

The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

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关于此项目

主要文件

属性

产品名称

SMILES string

InChI

InChI key

assay

form

manufacturer/tradename

storage condition

color

solubility

shipped in

storage temp.

Quality Level

相关类别

说明

Disclaimer

General description

Other Notes

Packaging

Preparation Note

Legal Information

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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