616431
反苯环丙胺盐酸盐
≥97% (HPLC), monoamine oxidase and histone demethylase inhibitor, solid
别名:
反苯环丙胺，盐酸盐，1X500MG, 组蛋白赖氨酸脱甲基酶抑制剂I，LSD抑制剂V，单胺氧化酶抑制剂I，反苯环丙胺，2-PCPA，TCP，(1R)-2-苯基环丙烷-1-胺盐酸盐，反式-2-苯基环丙胺盐酸盐，BHC110抑制剂V，LSD2抑制剂I，MOA抑制剂I，
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关于此项目
经验公式（希尔记法）:
C9H11N · xHCl
化学文摘社编号:
分子量:
133.19 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
产品名称
反苯环丙胺盐酸盐, A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities.
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white to yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Cl.N[C@@H]1[C@H](C1)c2ccccc2
InChI
1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m1./s1
InChI key
ZPEFMSTTZXJOTM-RJUBDTSPSA-N
General description
一种细胞可渗透性苯环丙胺，通过与酶结合FAD形成共价加合物，可分别抑制MAO A/B（Ki分别为101.9M和16.0M）和LSD1/2（Ki分别为242.7M和180.0 M）的单胺氧化酶和组蛋白去甲基化酶活性，MAO A/B和LSD1/2是黄素依赖性胺氧化酶家族的四个成员。除了防止LSD1-CoREST（RE1沉默转录因子的共抑制因子）复合物介导的H3K4去甲基化（IC50<2 M）外，TCP还抑制LSD1-HCF-1（宿主细胞因子-1）复合物介导的H3K9去甲基化酶活性，这被证明是α-疱疹病毒HSV和VZV复制和潜伏性感染的基本机制。据报告，2 M TCP和10 M CHIR99061的联合治疗，可使Oct4/Klf4-转导的原代HNEKs（人新生儿表皮角化细胞）重新编码到iPS细胞（诱导多功能干细胞）中，尽管在用4-TFs（Oct44、Klf4、Sox2和c-Myc）转导的培养物中，效率较低100倍。
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Liang, Y., et al. 2009.Nat. Med.15, 1312.
Li, W., et al. 2009.Stem Cells27, 2992.
Karytinos, A., et al. 2009.J. Biol. Chem.284, 17775.
Hruschka, S., et al. 2008.Bioorg.Med. Chem.16, 7148.
Schmidt, D.M., and McCafferty, D.G.2007.Biochemistry46, 4408.
Lee, M.G., et al. 2006.Chem. Biol.13, 563.
Yoshida, S., et al. 2004.Bioorg.Med. Chem.12, 2645.
Li, W., et al. 2009.Stem Cells27, 2992.
Karytinos, A., et al. 2009.J. Biol. Chem.284, 17775.
Hruschka, S., et al. 2008.Bioorg.Med. Chem.16, 7148.
Schmidt, D.M., and McCafferty, D.G.2007.Biochemistry46, 4408.
Lee, M.G., et al. 2006.Chem. Biol.13, 563.
Yoshida, S., et al. 2004.Bioorg.Med. Chem.12, 2645.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3