616453
TGF-β RI Kinase Inhibitor III
The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
TGF-β RI Kinase Inhibitor III, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
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关于此项目
经验公式（希尔记法）:
C20H21N3O2 · xHCl
化学文摘社编号:
分子量:
335.40 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
Cl.[nH]1c(nc(c1c3cc4c(cc3)OCO4)c2nc(ccc2)C)C(C)(C)C
InChI
1S/C20H21N3O2.ClH/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;/h5-10H,11H2,1-4H3,(H,22,23);1H
InChI key
BTUOOXPZOVNPMF-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
light yellow
solubility
DMSO: 20 mg/mL, water: 3 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Activin receptor-like kinase 4, 5, 7
Activin receptor-like kinase 4, 5, 7
Product competes with ATP.
Reversible: yes
Target IC50: 129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol.289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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