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616454

A 83-01

Name: A 83-01
Brand: MM

≥97% (HPLC), solid, TGF-β RI kinase inhibitor, Calbiochem

别名:

TGF-β RI 激酶抑制剂 IV

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关于此项目

经验公式（希尔记法）:

C₂₅H₁₉N₅S

化学文摘社编号:

909910-43-6

分子量:

421.52

MDL number:

MFCD08705403

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

200

Storage condition:

OK to freeze, protect from light

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属性

产品名称

TGF-β RI 激酶抑制剂 IV, TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC₅₀ = 45, 12, and 7.5 nM, respectively).

Quality Level

200

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

S=C([n]2nc(c(c2)c4c5c(ncc4)cccc5)c3nc(ccc3)C)Nc1ccccc1

InChI

1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)

InChI key

HIJMSZGHKQPPJS-UHFFFAOYSA-N

说明

General description

一种细胞渗透性三取代吡唑化合物，已显示在表达单个I型TGF-β受体的Mv1Lu R4-2转染子中选择性抑制ALK-4/5/7介导（荧光素酶转录活性测定中IC₅₀分别为45、12和7.5 nM），但不抑制ALK-1/2/3/6介导的细胞信号。在浓度为1 µM的情况下，抑制HaCaT细胞中TGF-β-诱导的Smad2磷酸化和NMuMG细胞中的上皮间质转化。

Biochem/physiol Actions

主要靶标
ALK-4/5/7

产物不与ATP竞争。

可逆：否

细胞可渗透性：是

靶标IC₅₀：抑制ALK-4/5/7介导的荧光素酶转录活性测定分别为45、12和7.5 nM

Packaging

用惰性气体包装

Preparation Note

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。

Other Notes

Tojo, M., et al. 2005.Cancer Sci.96, 791.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：有害（C）

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存储类别

11 - Combustible Solids

wgk

WGK 3

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货号	GTIN
616454-2MG	04055977185867