616464
SB 431542 hydrate
≥97% (HPLC), liquid, TGF-β RI kinase inhibitor, Calbiochem®
别名:
InSolution TGF-β RI激酶抑制剂VI，SB431542
登录查看公司和协议定价
关于此项目
经验公式（希尔记法）:
C22H16N4O3 · 2H2O
CAS Number:
分子量:
420.42
MDL编号:
UNSPSC代码:
51111800
NACRES:
NA.77
Product Name
TGF-β RI激酶抑制剂VI，SB431542, InSolution, ≥97%
质量水平
方案
≥97% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
运输
ambient
储存温度
−20°C
SMILES字符串
[nH]1c(nc(c1c4cc5c(cc4)OCO5)c3ncccc3)c2ccc(cc2)C(=O)N
InChI
1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChI key
FHYUGAJXYORMHI-UHFFFAOYSA-N
相关类别
一般描述
一种细胞渗透性三芳基咪唑化合物，经证明可有效抑制NIH 3T3细胞中组成性活性ALK4、ALK5或ALK7的载体介导表达后的细胞Smad2磷酸化（10 µM抑制剂抑制>90%），而在表达活性ALK1、2、3或6的NIH 3T3培养物中，TGF-βⅠ型受体的其他成员对Smad1磷酸化几乎没有影响。 当在无细胞激酶分析中直接测试时，SB431542被证明能有效抑制ALK4和ALK5的活性（IC50分别为140 nM和94 nM），而对包括ALK2和ALK6在内的24种其他激酶（IC50在10 µM ATP存在下为≥10 µM）没有效力或大大降低效力。据报道，当与PD0325901（目录号444966）和噻唑维文（目录号420220）一起使用时，4-TF诱导的成纤维细胞培养产生人类IPSC的效率提高了>200倍。
包装
用惰性气体包装
外形
100 mM (5 mg/119 µl) SB431542（目录号616461）在DMSO中的溶液。
制备说明
初次融化后，等分并冷冻（-20°C）。
其他说明
Ikushima, H., et al. 2009.Cell Stem Cell5, 504.
Lin, T., et al. 2009.Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009.Curr.Biol.19, 1718.
Callahan, J.F., et al. 2002.J. Med. Chem.45, 999.
Inman, G.J., et al. 2002.Mol.Pharmacol.62, 65.
Laping, N.J., et al. 2002.Mol.Pharmacol.62, 58.
Lin, T., et al. 2009.Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009.Curr.Biol.19, 1718.
Callahan, J.F., et al. 2002.J. Med. Chem.45, 999.
Inman, G.J., et al. 2002.Mol.Pharmacol.62, 65.
Laping, N.J., et al. 2002.Mol.Pharmacol.62, 58.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：刺激性（B）
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - (refers to pure substance)
闪点(°C)
87 °C - (refers to pure substance)
Jorian D Hapeman et al.
BMC ecology and evolution, 23(1), 39-39 (2023-08-22)
In spite of extensive research, cancer remains a major health problem worldwide. As cancer progresses, cells acquire traits that allow them to disperse and disseminate to distant locations in the body - a process known as metastasis. While in the
Xin-Yi Xu et al.
Frontiers in molecular biosciences, 9, 835508-835508 (2022-03-05)
Hepatic stellate cells (HSCs) play an essential role in the development of liver fibrosis. Antrodia camphorata (A. camphorata) is a medicinal fungus with hepatoprotective effect. This study investigated whether Antrodin C, an A. camphorata-fermented metabolite, could exert a protective role
Mine Koprulu et al.
The Journal of clinical endocrinology and metabolism, 107(4), 1065-1077 (2021-12-08)
Biological and translational insights from large-scale, array-based genetic studies of fat distribution, a key determinant of metabolic health, have been limited by the difficulty in linking predominantly noncoding variants to specific gene targets. Rare coding variant analyses provide greater confidence
Ming-An Sun et al.
Molecular biology and evolution, 38(11), 4992-5004 (2021-07-29)
In mammals, the placenta mediates maternal-fetal nutrient and waste exchange and acts in an immunomodulatory way to facilitate maternal-fetal tolerance. The placenta is highly diverse across mammalian species, yet the molecular mechanisms that distinguish the placenta of human from other
Robert Morey et al.
iScience, 27(4), 109569-109569 (2024-04-16)
Preeclampsia (PE) is a hypertensive pregnancy disorder with increased risk of maternal and fetal morbidity and mortality. Abnormal extravillous trophoblast (EVT) development and function is considered to be the underlying cause of PE, but has not been previously modeled in vitro.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持