616464
SB 431542 hydrate
≥97% (HPLC), liquid, TGF-β RI kinase inhibitor, Calbiochem®
别名:
InSolution TGF-β RI激酶抑制剂VI，SB431542
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关于此项目
经验公式（希尔记法）:
C22H16N4O3 · 2H2O
化学文摘社编号:
分子量:
420.42
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77
产品名称
TGF-β RI激酶抑制剂VI，SB431542, InSolution, ≥97%
SMILES string
[nH]1c(nc(c1c4cc5c(cc4)OCO5)c3ncccc3)c2ccc(cc2)C(=O)N
InChI
1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChI key
FHYUGAJXYORMHI-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
ambient
storage temp.
−20°C
Quality Level
Disclaimer
毒性：刺激性（B）
General description
一种细胞渗透性三芳基咪唑化合物，经证明可有效抑制NIH 3T3细胞中组成性活性ALK4、ALK5或ALK7的载体介导表达后的细胞Smad2磷酸化（10 µM抑制剂抑制>90%），而在表达活性ALK1、2、3或6的NIH 3T3培养物中，TGF-βⅠ型受体的其他成员对Smad1磷酸化几乎没有影响。 当在无细胞激酶分析中直接测试时，SB431542被证明能有效抑制ALK4和ALK5的活性（IC50分别为140 nM和94 nM），而对包括ALK2和ALK6在内的24种其他激酶（IC50在10 µM ATP存在下为≥10 µM）没有效力或大大降低效力。据报道，当与PD0325901（目录号444966）和噻唑维文（目录号420220）一起使用时，4-TF诱导的成纤维细胞培养产生人类IPSC的效率提高了>200倍。
Other Notes
Ikushima, H., et al. 2009.Cell Stem Cell5, 504.
Lin, T., et al. 2009.Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009.Curr.Biol.19, 1718.
Callahan, J.F., et al. 2002.J. Med. Chem.45, 999.
Inman, G.J., et al. 2002.Mol.Pharmacol.62, 65.
Laping, N.J., et al. 2002.Mol.Pharmacol.62, 58.
Lin, T., et al. 2009.Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009.Curr.Biol.19, 1718.
Callahan, J.F., et al. 2002.J. Med. Chem.45, 999.
Inman, G.J., et al. 2002.Mol.Pharmacol.62, 65.
Laping, N.J., et al. 2002.Mol.Pharmacol.62, 58.
Packaging
用惰性气体包装
Physical form
100 mM (5 mg/119 µl) SB431542（目录号616461）在DMSO中的溶液。
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - (refers to pure substance)
flash_point_c
87 °C - (refers to pure substance)
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